Hyperuricemia in Kidney Disease: A Major Risk Factor for Cardiovascular Events, Vascular Calcification, and Renal Damage
Kidney disease, especially when it is associated with a reduction in estimated glomerular filtration rate, can be associated with an increase in serum urate (uric acid), suggesting that hyperuricemia in subjects with kidney disease may be a strictly secondary phenomenon. Mendelian randomization studies that evaluate genetic scores regulating serum urate also generally have not found evidence that serum urate is a causal risk factor in chronic kidney disease. Nevertheless, this is countered by a large number of epidemiologic, experimental, and clinical studies that have suggested a potentially important role for uric acid in kidney disease and cardiovascular disease.
Source: Seminars in Nephrology - Category: Urology & Nephrology Authors: A. Ahsan Ejaz, Takahiko Nakagawa, Mehmet Kanbay, Masanari Kuwabara, Ada Kumar, Fernando E. Garcia Arroyo, Carlos Roncal-Jimenez, Fumihiko Sasai, Duk-Hee Kang, Thomas Jensen, Ana Andres Hernando, Bernardo Rodriguez-Iturbe, Gabriela Garcia, Dean R Tolan, La Source Type: research
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