Defining the index lesion for potential salvage partial or hemi-gland ablation after radiation therapy for localized prostate cancer

CONCLUSIONS: In men with recurrent prostate cancer after radiotherapy, biopsy findings and MRI can be used to select index lesions potentially amenable for sPGA and can guide patient evaluation for inclusion in clinical trials of sPGA following radiation failure. Larger, prospective studies are required to evaluate both the role of MRI and clinical criteria in guiding focal salvage therapy and the effectiveness of this modality for radiorecurrent prostate cancer.PMID:33583697 | DOI:10.1016/j.urolonc.2021.01.011
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Source Type: research

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Maybe one of your patients could benefit from the late-phase clinical trials that are currently recruiting men with various stages of prostate cancer.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
In conclusion, a solitary thickened extraocular eye muscle should be recognized in time and examined further.Case Rep Ophthalmol 2021;12:870 –874
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
Oligometastatic prostate cancer (PCa) can be defined as cancer with a limited number of metastases, typically fewer than 5 lesions, and involves lesions contained within the axial versus the appendicular skeleton. Patients can present with de novo oligometastatic, oligorecurrent, or oligoprogressive PCa. Oligometastatic PCa patients demonstrate considerable improvements in survival outcomes, with a better prognosis than patients with extensive metastatic disease. However, the management of patients that present with nonsymptomatic oligometastatic PCa remains difficult. In the oligometastatic setting, the benefit of local t...
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
Curr Issues Mol Biol. 2021 Oct 10;43(3):1518-1528. doi: 10.3390/cimb43030107.ABSTRACTThe goal of this study was to investigate whether Ducrosia flabellifolia and Savignya parviflora methanol extract the have effect on colon and prostate cancer cell lines. Analysis of total content of phenolics and flavonoids of each plant extract was carried out. Cytotoxic effect, cell cycle analysis, induction of apoptosis and gene expression of Bcl-2 and Bax genes were studied. Obtained results indicated that, the plant extracts exhibit growth inhibition of used cancer cell lines and induced apoptosis as well as arresting of cell cycle. ...
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research
An approach for eliminating racial disparities in breast and lung cancer treatmen...Read more on AuntMinnie.comRelated Reading: Accuray touts CyberKnife results in breast cancer radiation therapy RefleXion to showcase tech, abstracts at ASTRO 2021 Black individuals may not benefit from wider lung screening guidance Regulatory complexity challenges radiology administrators Radiation therapy takes toll on prostate cancer patients' finances
Source: Headlines - Category: Radiology Source Type: news
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
The use of brachytherapy for the definitive treatment of localized prostate cancer has been established for over four decades (1). Therapy may be delivered using either permanent seed low dose rate (LDR) or high dose rate (HDR) technique. Both techniques are recommended in the ASCO/CCO joint guidelines (2), and data suggests comparable oncologic outcomes. Brachytherapy may be used as monotherapy for low risk and selected intermediate risk patients or in conjunction with external beam radiation therapy (EBRT) for unfavorable intermediate and high risk patients.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Effective in situ cancer vaccines require both a means of tumor cell death and a source of adjuvant to activate local dendritic cells. Studies have shown that the use of radiotherapy (RT) to induce tumor cell death and anti-CD40 to activate dendritic cells can result in in situ vaccination in animal models. Here, investigations are carried out on potential strategies to enhance such in situ vaccination. Strategies investigated include the use of smart immunogenic biomaterials (IBM) loaded with anti-CD40 in different tumor types including immunologically cold tumors like pancreatic and prostate tumors. The use of downstream...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
hsen Beheshti Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and staging of the primary PCa. Magnetic resonance imaging (MRI) and computed tomography (CT) play crucial roles; however, functional imaging provides additional valuable information, and it is gaining ever-growing acceptance in the management of PCa. Targeted imaging with different radiotracers has remarkably evolved i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Accuray is highlighting clinical results that suggest that early-stage breas...Read more on AuntMinnie.comRelated Reading: Accuray reports revenue gains for Q1 Accuray to introduce Volo Ultra at ASTRO 2021 Accuray inks collaboration with C-RAD Accuray promotes prostate cancer research at ESTRO 2021 Accuray lands Radixact install in India
Source: Headlines - Category: Radiology Source Type: news
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