Modulation of human T-type calcium channels by synthetic cannabinoid receptor agonists in vitro

CONCLUSIONS AND IMPLICATIONS: SCRAs are potent agonists of CB1 receptors and can be extremely toxic, but observed toxicity also resembles symptoms associated with altered Cav3.2 activity. Many SCRAs tested were potent modulators of Cav3.2, raising the possibility that SC toxicity may be due in part to Cav3.2 modulation. This potent T-type channel modulation suggests the possibility of SCRAs as a new drug class with potential to treat diseases associated with altered T-type channel activity.PMID:33600843 | DOI:10.1016/j.neuropharm.2021.108478

Source: Neuropharmacology - February 18, 2021 Category: Drugs & Pharmacology Authors: Chris Bladen Somayeh Mirlohi Marina Santiago Mitchell Longworth Michael Kassiou Sam Banister Mark Connor Source Type: research