Role of 5-ht1a and 5-ht2c receptors of the dorsal periaqueductal gray in the anxiety- and panic-modulating effects of antidepressants in rats.

ROLE OF 5-HT1A AND 5-HT2C RECEPTORS OF THE DORSAL PERIAQUEDUCTAL GRAY IN THE ANXIETY- AND PANIC-MODULATING EFFECTS OF ANTIDEPRESSANTS IN RATS. Behav Brain Res. 2021 Feb 08;:113159 Authors: Vilela-Costa HH, Maraschin JC, Casarotto PC, Sant'Ana AB, de Bortoli VC, Vicente MA, de Campos AC, Guimarães FS, Zangrossi H Abstract Antidepressant drugs are first-line treatment for panic disorder. Facilitation of 5-HT1A receptor-mediated neurotransmission in the dorsal periaqueductal gray (dPAG), a key panic-associated area, has been implicated in the panicolytic effect of the selective serotonin reuptake inhibitor fluoxetine. However, it is still unknown whether this mechanism accounts for the antipanic effect of other classes of antidepressants drugs (ADs) and whether the 5-HT interaction with 5-HT2C receptors in this midbrain area (which increases anxiety) is implicated in the anxiogenic effect caused by short-term treatment with ADs. The results showed that previous injection of the 5-HT1A receptor antagonist WAY-100635 in the dPAG blocked the panicolytic-like effect caused by chronic systemic administration of the tricyclic AD imipramine in male Wistar rats tested in the elevated T-maze. Neither chronic treatment with imipramine nor fluoxetine changed the expression of 5-HT1A receptors in the dPAG. Treatment with these ADs also failed to significantly change ERK1/2 (extracellular-signal regulated kinase) phosphorylation level in this midbr...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research