Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study)

This study evaluates the relationship betweenACAT1 andAPOE genetic variants with susceptibility for the development of Alzheimer ’s disease and other dementias. We examined fourACAT1 polymorphisms (rs2247071, rs2862616, rs3753526, rs1044925) and two in theAPOE gene (rs7412, rs429358) in a group of 204 controls and 196 cases of dementia. Our results show one protective haplotype: CGCA (OR  = 0.34, 95% CI = 0.23–0.46;p <  0.001) and one risk haplotype: CGGA (OR = 1.87, 95% CI = 1.34–2.60;p <  0.001) for the development of dementia. Subjects identified asAPOE-ε4 allele carriers had a higher risk of developing dementia compared with non-carriers, OR  = 13.33 (95% CI = 3.14–56.31). The results support the hypothesis that theACAT1 gene, together with theAPOE gene, plays an important role in susceptibility to the development of dementia and shows genetic characteristics of the Mexican population that can be used to identify the population at risk.
Source: Molecular Neurobiology - Category: Neurology Source Type: research