DNA-cleavage activity of the iron(II) complex with optically active ligands, meta- and para-xylyl-linked N',N'-dipyridylmethyl-cyclohexane-1,2-diamine.

In this study, to develop novel compounds with specific DNA-cleavage activities, we synthesized optically active binuclear ligands, (1R,1'R,2R,2'R)-N1,N1'-(meta/para-phenylenebis(methylene))bis(N2,N2-bis(pyridin-2-ylmethyl)cyclohexane-1,2-diamine) and their enantiomers. The DNA-cleavage activities of these compounds were investigated in the presence of Fe(II)SO4 and sodium ascorbate. The obtained results indicated that the Fe(II) complexes of those compounds efficiently cleave DNA and that their cleavage was subtle sequence-selective. Therefore, we succeeded in developing compounds that can be used as small-molecule drugs for cancer chemotherapy.
PMID: 33540045 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - February 1, 2021 Category: Chemistry Authors: Kato K, Ichimaru Y, Okuno Y, Yamaguchi Y, Jin W, Fujita M, Otsuka M, Imai M, Kurosaki H Tags: Bioorg Med Chem Lett Source Type: research