Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin [Cell Biology]

Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown. To address this question, we performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose...

Source: Proceedings of the National Academy of Sciences - January 25, 2021 Category: Science Authors: Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine Tags: Biological Sciences Source Type: research