Diminished substrate ‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats

ConclusionAltered cardiac mitochondrial respiration and autophagy were observed in adult male ODM compared to OCM, while the male and female offspring at weaning stage were less affected. The results of the study show that maternal hyperglycemia affects mitochondrial respiration and autophagy in the ODM heart, which may potentially be responsible for the cardiovascular complications observed in adult life.This article is protected by copyright. All rights reserved.

Source: IUBMB Life - January 22, 2021 Category: Research Authors: Raji Sasikala Rajendran, Nandini Ravikumar Jayakumari, Ashok Sivasailam, Anand Chellappan Reghuvaran, Vivek Velayudhan Pillai, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha, Shankarappa Manjunatha, Srinivas Gopala Tags: RESEARCH COMMUNICATION Source Type: research