Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors.

This study shows for the first time that KOR activation increases activity of amygdala CRF neurons through synaptic disinhibition, resulting in averse-affective pain-like behaviors. Blocking KOR receptors may therefore represent a novel therapeutic strategy. PMID: 33444637 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33444637?dopt=Abstract

Source: Neuropharmacology - January 11, 2021 Category: Drugs & Pharmacology Authors: Hein M, Ji G, Tidwell D, D'Souza P, Kiritoshi T, Yakhnitsa V, Navratilova E, Porreca F, Neugebauer V Tags: Neuropharmacology Source Type: research