Modification of ventriculo –arterial coupling by spironolactone in nonischemic dilated cardiomyopathy
ConclusionsIn NIDCM, adding MRA to conventional anti ‐failure therapy markedly improved LV ejection fraction and reduced peripheral vascular resistance, due to both improved LV contractility and especially to enhanced V–A coupling, as Ea decreased to normal. Total circulatory performance was a sensitive indicator of both LV pump performance and th e arterial loading conditions.
Source: ESC Heart Failure - Category: Cardiology Authors: Mark A. Lawson,
David E. Hansen,
Deepak K. Gupta,
Susan P. Bell,
Douglas W. Adkisson,
Ravinder R. Mallugari,
Douglas B. Sawyer,
Henry Ooi,
Marvin W. Kronenberg Tags: Original Research Article Source Type: research
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