Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review.

Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review. Am J Med Sci. 2020 Dec 17;: Authors: Tfaily MAH, Titanji B, Schniederjan MJ, Goodman A, Lava NS, Pouch SM, Collins MH, Adelman MW Abstract In this patient-focused review, we present a 34-year-old previously healthy man admitted for fever and headache two weeks after a motor vehicle accident. On admission, his workup was concerning for meningoencephalitis based on elevated cerebrospinal fluid (CSF) white blood cell count and elevated CSF protein. He was admitted for management of meningoencephalitis. During his course, no causative infectious agent was identified despite an extensive workup. He additionally underwent an autoimmune and paraneoplastic workup that was negative. During his hospitalization, he developed acute transverse myelitis manifested by bilateral lower extremity paralysis. After four weeks marked by persistent clinical deterioration, brain biopsy was performed. Pathologic examination was consistent with neuromyelitis optica spectrum disorder (NMOSD). In this case report and literature review, we explore the presentations of NMOSD that mimic an infection. Clinicians should be aware of the possibility of NMOSD masquerading as infectious meningoencephalitis or acute transverse myelitis. PMID: 33342552 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research