Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki.

CONCLUSION: This study applied computational and bioinformatics methods in generating AOPs for arsenic reproductive toxicity, which identified the imperative roles of testosterone reduction, response to ROS, spermatogenesis and give a global view about their internal association. Furthermore, this study helped address the existing knowledge gaps for future experimental verification.
PMID: 33338516 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - December 15, 2020 Category: Toxicology Authors: Chai Z, Zhao C, Jin Y, Wang Y, Zou P, Ling X, Yang H, Zhou N, Chen Q, Sun L, Chen W, Ao L, Cao J, Liu J Tags: Toxicol Appl Pharmacol Source Type: research