Polyclonality, Shared Strains, and Convergent Evolution in Chronic CF S. aureus Airway Infection.

CONCLUSIONS: CF airways are frequently co-infected by multiple, genetically distinct S. aureus lineages, indicating that current clinical procedures for sampling isolates and selecting antibiotics are likely inadequate. Strains can be shared by patients in close domestic or clinical contact and undergo convergent evolution in key persistence and antimicrobial resistance genes, suggesting novel diagnostic and therapeutic approaches for future study. PMID: 33296290 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research