Human superoxide dismutase 1 attenuates quinoneimine metabolite formation from mefenamic acid.

In conclusion, we found that SOD1 can serve as a detoxification enzyme for quinoneimines to protect from drug-induced toxicity.
PMID: 33259822 [PubMed - as supplied by publisher]

Source: Toxicology - November 28, 2020 Category: Toxicology Authors: Ogiso T, Fukami T, Zhongzhe C, Konishi K, Nakano M, Nakajima M Tags: Toxicology Source Type: research