Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.

CONCLUSIONS: We demonstrate a novel association between gonadotoxic treatments and advanced stages of reproductive aging. Without endocrine biomarkers, bleeding pattern alone can misclassify AYA survivors into either more or less advanced stages. Moreover, a large proportion of AYA survivors exhibited combinations of endocrine biomarkers and bleeding patterns that do not fit STRAW+10 criteria, suggesting the need for modified staging for this population.
PMID: 33141175 [PubMed - as supplied by publisher]

Source: Clinical Genitourinary Cancer - November 3, 2020 Category: Cancer & Oncology Authors: Medica ACO, Whitcomb BW, Shliakhsitsava K, Dietz A, Pinson K, Lam C, Romero SAD, Sluss P, Sammel MD, Su HI Tags: J Clin Endocrinol Metab Source Type: research