Development of aldose reductase inhibitors for the treatment of inflammatory disorders and cancer: current drug design strategies and future directions.

Development of aldose reductase inhibitors for the treatment of inflammatory disorders and cancer: current drug design strategies and future directions.
Curr Med Chem. 2020 Oct 27;:
Authors: Sonowal H, Ramana KV
Abstract
Aldose Reductase (AR) is an enzyme that converts glucose to sorbitol during the polyol pathway of glucose metabolism. AR has been shown to be involved in the development of secondary diabetic complications due to its involvement in causing osmotic stress as well as oxidative stress. Various AR inhibitors have been tested for their use to treat secondary diabetic complications such as retinopathy, neuropathy, and nephropathy in clinical studies. Recent studies also suggest the potential role of AR in mediating various inflammatory complications. Therefore, the studies on the development and potential use of AR inhibitors to treat inflammatory complications and cancer besides diabetes currently are on rising. Further, genetic mutagenesis studies, computer modeling, and molecular dynamics studies have helped design novel and potent AR inhibitors. This review discussed the potential new therapeutic use of AR inhibitors in targeting inflammatory disorders and cancer besides diabetic complications. Further, we summarized recent studies on how AR inhibitors have been designed and developed for therapeutic purposes in the last few decades.
PMID: 33109031 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - October 27, 2020 Category: Chemistry Authors: Sonowal H, Ramana KV Tags: Curr Med Chem Source Type: research