Anxiolytic and antioxidant effects of Euterpe oleracea Mart. (a çaí) seed extract in adult rat offspring submitted to periodic maternal separation

In conclusion, ASE treatment has an anti-anxiety effect in rats submitted to PMS by reducing hypothalamic–pituitary–adrenal axis reactivity and increasing th e nitric oxide (NO)–brain-derived neurotrophic factor (BDNF)–TRKB pathway and antioxidant defense in the central nervous system. Novelty ASE has anti-anxiety and antioxidant effects in early-life stress. ASE reduces hypothalamic–pituitary–adrenal axis reactivity. The anxiolytic effect of AS E may involve activation of the NO–BDNF–TRKB pathway in the central nervous system.

Source: Applied Physiology, Nutrition, and Metabolism - June 9, 2020 Category: Physiology Authors: Graziele Freitas de Bem Anicet Okinga Dayane Teixeira Ognibene Cristiane Aguiar da Costa Izabelle Barcellos Santos Ricardo Andrade Soares Dafne Lopes Beserra Silva Ana Paula Machado da Rocha Jemima Isnardo Fernandes Mabel Carneiro Fraga Cl áudio Carneiro Source Type: research