Fibroblast Nox2 (NADPH Oxidase-2) Regulates ANG II (Angiotensin II)-Induced Vascular Remodeling and Hypertension via Paracrine Signaling to Vascular Smooth Muscle Cells.

CONCLUSIONS: These results indicate that fibroblast Nox2 plays a crucial role in the development of ANG II-induced vascular remodeling and hypertension in vivo. Mechanistically, fibroblast Nox2 may regulate paracrine signaling to medial vascular smooth muscle cells via factors, such as GDF6.
PMID: 33054395 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 15, 2020 Category: Cardiology Authors: Harrison CB, Trevelin SC, Richards DA, Santos CXC, Sawyer G, Markovinovic A, Zhang X, Zhang M, Brewer AC, Yin X, Mayr M, Shah AM Tags: Arterioscler Thromb Vasc Biol Source Type: research