Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice

Opioids are commonly prescribed for postoperative pain77 or severe neuropathic pain.75 However, many patients continue to consume opioids well after surgery21 due to continued pain18 or postsurgical opioid over-prescription.5, 40 Analgesic tolerance developing after repeated opioid consumption7 further increases the risk of developing opioid dependence, withdrawal and/or overdose.38, 68 Therefore, unresolved severe chronic pain or opioid over-prescription may lead to opioid use disorder,22, 23 contributing to the ongoing opioid crisis.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research