Glioma Pericytes Promote Angiogenesis by Producing Periostin.

Glioma Pericytes Promote Angiogenesis by Producing Periostin. Cell Mol Neurobiol. 2020 Oct 03;: Authors: Bernardes SS, Pinto MCX, Amorim JH, Azevedo VAC, Resende RR, Mintz A, Birbrair A Abstract Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas. PMID: 33010018 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33010018?dopt=Abstract

Source: Cellular and Molecular Neurobiology - October 2, 2020 Category: Cytology Authors: Bernardes SS, Pinto MCX, Amorim JH, Azevedo VAC, Resende RR, Mintz A, Birbrair A Tags: Cell Mol Neurobiol Source Type: research