Cancers, Vol. 12, Pages 2859: Immunotherapy for Hepatocellular Carcinoma: A 2021 Update
Cancers, Vol. 12, Pages 2859: Immunotherapy for Hepatocellular Carcinoma: A 2021 Update
Cancers doi: 10.3390/cancers12102859
Authors:
Kole
Charalampakis
Tsakatikas
Vailas
Moris
Gkotsis
Kykalos
Karamouzis
Schizas
Hepatocellular carcinoma (HCC) is one of one of the most frequent liver cancers and the fourth leading cause of cancer-related mortality worldwide. Current treatment options such as surgery, neoadjuvant chemoradiotherapy, liver transplantation, and radiofrequency ablation will benefit only a very small percentage of patients. Immunotherapy is a novel treatment approach representing an effective and promising option against several types of cancer. The aim of our study is to present the currently ongoing clinical trials and to evaluate the efficacy of immunotherapy in HCC. In this paper, we demonstrate that combination of different immunotherapies or immunotherapy with other modalities results in better overall survival (OS) and progression­free survival (PFS) compared to single immunotherapy agent. Another objective of this paper is to demonstrate and highlight the importance of tumor microenvironment as a predictive and prognostic marker and its clinical implications in immunotherapy response.
Source: Cancers - Category: Cancer & Oncology Authors: Kole Charalampakis Tsakatikas Vailas Moris Gkotsis Kykalos Karamouzis Schizas Tags: Review Source Type: research