Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone
Conclusion: Our results revealed that restraint stress/CORT increased HSV-1 susceptibility by delivering PML into autolysosomes for degradation. The results obtained from in vitro and in vivo models not only demonstrated the adverse effects of stress on HSV-1 infection, but also systematically investigated the underlying molecular mechanisms. These discoveries broaden our understanding of the interplay between host and viruses, and a comprehensive understanding of the role of autophagy in viral infection will provide information for future development of innovative drugs against viral infection.
Source: Theranostics - Category: Molecular Biology Authors: Wen Li, Zhuo Luo, Chang-Yu Yan, Xiao-Hua Wang, Zheng-Jie He, Shu-Hua Ouyang, Chang Yan, Li-Fang Liu, Qing-Qing Zhou, Han-Lu Mu, Hai-Biao Gong, Wen-Jun Duan, Lei Liang, Hiroshi Kurihara, Du Feng, Yi-Fang Li, Rong-Rong He Tags: Research Paper Source Type: research