Use of Microfluidics to Fabricate Bioerodable Lipid Hybrid Nanoparticles Containing Hydromorphone or Ketamine for the Relief of Intractable Pain

ConclusionsThe two-stage microfluidic method allowed efficient production of analgesic/adjuvant drug-loaded NPs. Our proof-of-principlein vivo study shows prolonged hydromorphone analgesic for 78  h after single i.t. injection. At the i.t. dose administered, ketamine released from NPs was insufficient to augment hydromorphone analgesia.

Source: Pharmaceutical Research - October 1, 2020 Category: Drugs & Pharmacology Source Type: research