Effect of medically lowering intraocular pressure in glaucoma suspects with high myopia (GSHM study): study protocol for a randomized controlled trial

DiscussionTo the best of our knowledge, the GSHM study is the first RCT to investigate the impact of medically lowering IOP in GSHM. The results will have implications for the clinical management of GSHM.Trial registrationClinicalTrials.govNCT04296916. Registered on 4 March 2020
Source: Trials - Category: Research Source Type: clinical trials

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To investigate whether progressive macular ganglion cell –inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning are predictive for detecting visual field (VF) progression in eyes with high myopia.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
Abstract Myopic eyes have an increased risk of glaucoma. However, glaucomatous changes in a myopic eye are often difficult to detect. Classic structural and functional investigations to diagnose glaucoma may be confounded by myopia. Here, we identify some of the common pitfalls in interpreting these structural parameters, and the possible solutions that could be taken to overcome them. For instance, in myopic eyes, we discuss the limitations and potential sources of error when using neuroretinal rim parameters, and retinal nerve fibre layer and ganglion cell-inner plexiform layer thickness measurements. In additio...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Abstract Background: Currently, spectral-domain optical coherence tomography (SD-OCT) appears to be a new type of glaucoma diagnostic tool. Thus, this study aimed to evaluate the effectiveness of glaucoma diagnostic parameters from SD-OCT of patients with different severities of myopia. Methods: This was a cross-sectional study. A total of 248 participants (248 eyes) were enrolled, including 51 cases in the early primary open-angle glaucoma group, 79 cases in the control group (0.50 D to -0.50 D, excluding -0.50 D), 47 cases in the low-myopic group (-0.50 to -3.00 D, excluding -3.00 D), 43 cases in the modera...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
CONCLUSION: In vivo OCT imaging and quantification of guinea pig retina and optic nerve head parameters were repeatable and similar between eyes of the same animal. In vivo visibility of retinal cell layers correlated well with histological images. PMID: 29641938 [PubMed - as supplied by publisher]
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Conclusions: ODT direction showed a significant association with the locations of β-PPA and PMRE of β-PPA. Torsional degree was correlated with the β-PPA angle in the myopic eyes of young patients with glaucomatous-appearing VFDs.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Abstract The macular area is important to the detection of glaucomatous retinal ganglion cell (RGC) damage. Macular thickness complementary to peripapillary retinal nerve fibre layer (RNFL) thickness can well reflect glaucomatous damage, given that the macula contains more than 50% of the RGCs in a multilayered pattern and larger RGC bodies compared with their axons. Thus, macular ganglion cell thickness parameters recently have been considered to be an effective glaucoma-diagnostic tool comparable to RNFL thickness parameters. Furthermore, spectral-domain optical coherence tomography ganglion cell-inner plexiform...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Conclusions: This study establishes normative macular GC-IPL and RNFL thickness in children with refractive errors. Our results suggest that high definition optical coherence tomography RNFL parameters and minimum GC-IPL are not affected by AL or myopia in children, and therefore warrants further evaluation in pediatric glaucoma patients.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
Purpose: To compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue-OCT) for ganglion cell complex (GCC) and retinal nerve fiber layer thickness (RNFLT) image segmentation and detection of glaucoma in high myopia. Materials and Methods: RNFLT and GCC scans were acquired with software version 6.3 of the RTVue-OCT on 51 highly myopic eyes (spherical refractive error ≤−6.0 D) of 51 patients, and were analyzed with both the software versions. Twenty-two eyes were nonglaucomatous, 13 were ocular hypertensive and 16 eyes had glaucoma. Results: No difference was...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Original Studies Source Type: research
Purpose: We compared the thickness of the ganglion cell–inner plexiform layer at the macula (mGCIPL) and the thickness of the retinal nerve fiber layer (RNFL) in different regions of the retina in eyes with primary open-angle glaucoma (POAG group) and normal eyes (control group). Design: This was a cross-sectional study performed in 2014. Methods: Spectral domain optical coherence tomography (SD-OCT) was used to measure mGCIPL and RNFL thickness. Age-adjusted means and standard deviation were calculated. Age, sex, refractive status, corneal thickness, and stage/severity of glaucoma (defined by vertical cup-to-disc ...
Source: Asia-Pacific Journal of Ophthalmology - Category: Opthalmology Tags: Original Study - Clinical Source Type: research
Conclusions: Repeatabilities of most of the SDOCT parameters in high-myopic subjects were good and comparable to that of emmetropic subjects. This suggests that SDOCT can be useful for following up high-myopic glaucoma patients to detect progression.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Original Studies Source Type: research
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