Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation

and purpose. Identification of appropriate dietary strategies for prevention of weight and muscle loss in cancer patients is crucial for successful treatment and prolonged patient survival. High-protein oral nutritional supplements decrease mortality and improve indices of nutritional status in cancer patients; however, high-protein diets are often rich in methionine, and experimental evidence indicates that a methionine-supplemented diet (MSD) exacerbates gastrointestinal toxicity after total body irradiation (TBI).

Source: International Journal of Radiation Oncology * Biology * Physics - September 27, 2020 Category: Radiology Authors: Laura E. Ewing, Charles M. Skinner, Rupak Pathak, Eric U. Yee, Kim Krager, Patrick C. Gurley, Stepan Melnyk, Marjan Boerma, Martin Hauer-Jensen, Igor Koturbash Source Type: research