Molecules, Vol. 25, Pages 4421: Apigenin and Hesperidin Downregulate DNA Repair Genes in MCF-7 Breast Cancer Cells and Augment Doxorubicin Toxicity

In conclusion, both apigenin and hesperidin enhance the cytotoxic effects of doxorubicin on breast cancer cells, and this phenomenon occurs regardless of oxidative stress but is accompanied by disorders of DNA damage response mechanisms.

Source: Molecules - September 25, 2020 Category: Chemistry Authors: Agnieszka Korga-Plewko Monika Michalczyk Grzegorz Adamczuk Ewelina Humeniuk Marta Ostrowska-Lesko Aleksandra Jozefczyk Magdalena Iwan Marta Wojcik Jaroslaw Dudka Tags: Article Source Type: research