Progranulin modulates cartilage-specific gene expression via sirtuin 1-mediated deacetylation of the transcription factors SOX9 and P65 [Gene Regulation]

In conclusion, our findings reveal a mechanism of action for PGRN that maintains cartilage homeostasis and supports the notion that PGRN up-regulation may be a promising strategy for managing OA.

Source: Journal of Biological Chemistry - September 24, 2020 Category: Chemistry Authors: Dongxu Feng, Xiaomin Kang, Ruiqi Wang, He Chen, Kun Zhang, Weilou Feng, Huixia Li, Yangjun Zhu, Shufang Wu Tags: Cell Biology Source Type: research