Melanoma brain metastases have lower T-cell content and microvessel density compared to matched extracranial metastases

ConclusionsAlthough responses to immune-modulating drugs in the body and the brain tend to be concordant, differences were found in MVD and T-cell content between these sites. Studies of these markers should be incorporated into prospective therapeutic clinical trials to determine their prognostic and predictive value.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research