Colorectal Cancer: Microsatellite Instability/Mismatch Repair Testing in the Era of Digital Pathology

It has been>15 years since universal microsatellite instability (MSI) or mismatch repair (MMR) testing has been recommend for all cases of colorectal carcinoma.1 MSI/MMR testing is a proven prognostic marker and can help identify patients with possible hereditary cancers (Lynch syndrome).2,3 More recently, checkpoint inhibition therapy has been found to be effective in tumors that demonstrate MSI, making MSI/MMR testing a pan-cancer therapeutic biomarker.4 Given its importance, multiple organizations, including the American Society of Clinical Oncology, Association for Molecular Pathology, College of American Pathologists, European Society for Medical Oncology, and National Institute for Health and Care Excellence, have advocated for reflective MSI or MMR testing on all colorectal adenocarcinomas.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Editorial Source Type: research