Comparative molecular profiling of distant metastatic and non-distant metastatic lung adenocarcinoma.

Comparative molecular profiling of distant metastatic and non-distant metastatic lung adenocarcinoma. Neoplasma. 2020 Sep 17;: Authors: Chen Z, Chen G, Wang Z, Yu J, Zhang H, Mao B, Ma H Abstract Most lung cancer deaths are caused by a distant disseminated disease rather than primary tumors. Understanding the biology behind distant metastasis (DM) is crucial for the effective prediction and reduction of recurrence rates. Genome-wide analysis of the tumor provides a new way to explore the pathogenesis and molecular diagnosis of metastasis in lung adenocarcinoma. In our study, a total of 215 eligible lung adenocarcinoma patients were enrolled. The DNA was extracted from Formalin-fixed paraffin-embedded (FFPE) samples from the primary tumors of these patients. Comprehensive molecular profiling was performed using a panel covering the exome of lung cancer-associated driver genes based on targeted next-generation sequencing. Tumor gene alterations were analyzed to investigate the differences in molecular features between lung adenocarcinomas with or without DM. Patients with DM of lung adenocarcinoma had significantly more variations in overall copy number (defined as Copy Number Alteration (CNA) load and Copy Number Instability (CNI) score). Interestingly, the study of the relationship between copy number variation and other molecular features verified that the degree of copy number variation has a positive correlation with mutations of ...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research