Retinoic acid signaling regulates proliferation and lamina formation in the developing chick optic tectum.

In this study, we have identified the presence of differential retinoic acid (RA) signaling along the rostro-caudal and dorsoventral axis of the tectum. We show for the first time that loss of RA signaling in the anterior optic tectum, leads to an increase in cell proliferation and gross changes in the morphology manifested as defects in lamination. Detailed analysis points to delayed migration of cells as the plausible cause for the defects in lamina formation. Thus, we conclude that in the optic tectum, RA signaling is involved in maintaining cell proliferation and in regulating the formation of the tectal laminae. PMID: 32919944 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32919944?dopt=Abstract

Source: Developmental Biology - September 9, 2020 Category: Biology Authors: Kukreja S, Udaykumar N, Yogesh B, Sen J Tags: Dev Biol Source Type: research