Dose to Lungs and Kidneys during Total Body Irradiation: Are We Delivering the Expected Dose?

Total Body irradiation (TBI)-based conditioning is key component for hemopoietic stem cell transplantation. TBI dose calculation is traditionally based on point-dose calculations based on estimates of body separation at different levels with the umbilicus as a reference point, an approach followed as standard protocol at most institutions. This homogenous dose calculation technique does not take into account tissue heterogeneity. Limited data exists for TPS-based TBI planning systems especially in the setting of lung and kidney partial transmission blocks, which is a void in our understanding of TBI dose delivery and is explored in this study.

Source: International Journal of Radiation Oncology * Biology * Physics - September 10, 2020 Category: Radiology Authors: Philip Damron, Santanu Samanta, Yannick Poirier, Serena Mao, Narottam Lamichhane, Byongyong Yi, Pranshu Mohindra Source Type: research