Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of non-reperfused myocardial infarction.

In conclusion, the reliability of autopsy in documentation of rupture in infarcted mice is dependent on the specific criteria used. Macrophage-driven inflammation and reduced activation of collagen-secreting reparative myofibroblasts may be involved in the pathogenesis of post-MI cardiac rupture. PMID: 32886000 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32886000?dopt=Abstract

Source: American Journal of Physiology. Heart and Circulatory Physiology - September 3, 2020 Category: Physiology Authors: Hanna A, Shinde AV, Frangogiannis NG Tags: Am J Physiol Heart Circ Physiol Source Type: research