Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity

In modern world obesity is one of the most important medical problem accompanied by critical complications (type 2 diabetes mellitus, cardiovascular diseases, oncology etc.) [1-3]. Crucial undesirable obesity-associated factor is insulin resistance, which leads to hyperglycemia, proteins glycation, dyslipidemia and inflammation [4-5]. Nevertheless, not all obese patients suffer from type 2 diabetes mellitus (T2DM) [6-8]. In present work we studied the role of beige differentiation potential of human adipose derived stromal cells (ADSC) in T2DM development of obese patients.

Source: Diabetes Research and Clinical Practice - August 30, 2020 Category: Endocrinology Authors: Michurina Svetlana, Stafeev Iurii, Podkuychenko Nikita, Sklyanik Igor, Shestakova Ekaterina, Yah'yaev Kamil, Yurasov Anatoliy, Ratner Elizaveta, Menshikov Mikhail, Parfyonova Yelena, Shestakova Marina Source Type: research