The multi-targets mechanism of hydroxychloroquine in the treatment of systemic lupus erythematosus based on network pharmacology.

CONCLUSIONS: Our research provides protein targets affected by HCQ in the treatment of SLE. Three key targets (CDK2, ESR1 and CDK1) involving 1766 proteins become the multi-targets mechanism of HCQ in the treatment of SLE. As well, the research also provides a new idea for introducing network pharmacology into the evaluation of the drugs with multi-targets in dermatology. PMID: 32854577 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32854577?dopt=Abstract

Source: Lupus - August 26, 2020 Category: Rheumatology Authors: Xie B, Geng Q, Xu J, Lu H, Luo H, Hu Y, Song X Tags: Lupus Source Type: research