Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome.

We examined the effects of salsalate treatment on nutrient-induced OS and inflammation, ovarian androgen secretion, ovulation and insulin sensitivity. Eight lean insulin-sensitive women with PCOS and 8 age- and body composition-matched ovulatory controls for baseline comparison participated in the study. The women with PCOS underwent a 12-week treatment of salsalate, a non-steroidal anti-inflammatory drug, at a dose of 3 gm daily. Markers of OS and inflammation were quantified in mononuclear cells (MNC) and plasma from blood drawn fasting and 2 hours after saturated fat ingestion, before and after treatment. Ovarian androgen secretion was assessed from blood drawn fasting and 24, 48 and 72 hours after human chorionic gonadotropin (HCG) administration, before and after treatment. Ovulation was documented based on biphasic basal body temperatures and luteal range progesterone elevations. A two-step pancreatic clamp was performed pre- and post-treatment to measure basal endogenous glucose production (EGP) and the steady state glucose disposal rate (GDR) during the euglycemic phase and markers of OS and inflammation in MNC and plasma during the hyperglycemic phase. Salsalate administration suppressed lipid- and glucose-stimulated reactive oxygen species generation, activated nuclear factor-κB and circulating tumor necrosis factorα, normalized basal androgen levels and lowered HCG-stimulated androgen secretion without altering EGP or GDR. Four salsalate-treated subjects responde...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research