Influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with Polycystic Ovary Syndrome: A systematic review and meta-analysis.

Influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with Polycystic Ovary Syndrome: A systematic review and meta-analysis. Br J Nutr. 2020 Aug 17;:1-31 Authors: Tosatti JAG, Alves MT, Cândido AL, Reis FM, Araújo VE, Gomes KB Abstract Polycystic ovary syndrome (PCOS) is defined as a reproductive endocrine disease that results in a low-grade inflammatory and prooxidant state. Dietary factors, including omega-3 fatty acids, may have a key role in improving metabolic disorders in PCOS patients. The present study aimed to investigate the influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with PCOS. A systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus and Lilacs, until November 2019, was conducted. Randomized clinical trials that reported inflammatory and oxidative stress markers as endpoints in women with PCOS receiving omega-3 fatty acid supplementation were included. The pooled estimates of the weighted mean differences (WMD) and the standard mean differences (SMD) were calculated. Random effect models were adopted to measure the pooled outcomes. Among the 323 studies retrieved, 10 fulfilled the inclusion criteria for a meta-analysis. We founded a significant decrease in high-sensitivity C-reactive protein (hs-CRP) [SMD: -0.29 (95%CI: -0.56 to -0.02) mg/L] and an increase of adi...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research