Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor

NIH funded pre-clinical study highlights intricate links between brain tumors and cancer.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news

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ConclusionCT exposure in childhood appears to be associated with increased risk of cancer while no significant association was observed with diagnostic radiographs.
Source: Pediatric Radiology - Category: Radiology Source Type: research
CONCLUSIONS: Visual acuity decline following radiotherapy for intracranial malignancies in children is rare. A dose of approximately 56 GyRBE to 0.1 cm3 results in an approximately 5% risk of visual acuity decline for children with suprasellar or optic pathway tumors. A dose to 0.1 cm3 of 56 GyRBE appears to be safe for children with tumors elsewhere in the brain. PMID: 32762400 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
ABSTRACT The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect stereotypical changes in the proliferative properties of neural progenitors. The temporal mechanisms underlying these proliferation patterns are still unclear in mammals. In Drosophila, two decades of work have revealed a network of sequentially expressed transcription factors and RNA-binding proteins t...
Source: DMM Disease Models and Mechanisms - Category: Biomedical Science Authors: Tags: Cancer, Developmental Disorders, Drosophila as a Disease Model REVIEW Source Type: research
ConclusionsVIQ and PIQ deficits persist in adulthood, suggesting the effect of a fixed injury imposing on cognitive development, rather than an ongoing pathological process.Implications for cancer survivorsThe findings will help parents and others supporting survivors of an early life PFT to identify and plan for possible cognitive outcomes, and highlight the importance of early interventions to optimize cognitive function during the developmental period.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Contributors : Anhaid Ehteda ; Sandy Simon ; Laura Franshaw ; Federico M Giorgi ; Jie Liu ; Elisha Hayden ; Swapna Joshi ; Chi N Pang ; Ruby Pandher ; Chelsea Mayoh ; Aaminah Khan ; Caitlin Ung ; Ornella Tolhurst ; Anne Kankean ; Anjana Gopalakrishnan ; Peter Trebilcock ; Katerina Gurova ; Andrei Gudkov ; Murray D Norris ; Michelle Haber ; Orazio Vittorio ; Maria Tsoli ; David S ZieglerSeries Type : Expression profiling by arrayOrganism : Homo sapiensDiffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. A high throughput drug screen of 3600 pharmac...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
ConclusionChildren with CMS face a variety of challenges affecting many aspects of their everyday lives. They should be entitled to the elements of a current rehabilitation initiative for childhood cancer to support patients ’ social disability and educational decline. Finally, we identified a need for an official information publication.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
As a highly aggressive pediatric brainstem tumor, diffuse intrinsic pontine glioma (DIPG) accounts for 10% to 20% of childhood brain tumors. The survival rate for DIPG remains very low, with a median survival time as less than one year even under radiotherapy, the current standard treatment. Moreover, over than 250 clinical trials have failed when trying to improve the survival compared to radiotherapy. The sphingolipid metabolism and related signaling pathways have been found closely related to cancer cell survival; however, the sphingolipid metabolism targeted therapies have never been investigated in DIPG. In the curren...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Pediatric cancers, particularly high-risk solid tumors, urgently need effective and specific therapies. Their outlook has not appreciably improved in decades. Immunotherapies such as immune checkpoint inhibitors offer much promise, but most are only approved for use in adults. Though several hundred clinical trials have tested immune-based approaches in childhood cancers, few have been guided by biomarkers or clinical-grade assays developed to predict patient response and, ultimately, to help select those most likely to benefit. There is extensive evidence in adults to show that immune profiling has substantial predictive ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Abstract Pediatric brain tumors are the leading cause of cancer-related death in children. Patient-derived orthotopic xenografts (PDOX) of childhood brain tumors have recently emerged as a biologically faithful vehicle for testing novel and more effective therapies. Herein, we provide the histopathological and molecular analysis of 37 novel PDOX models generated from pediatric brain tumor patients treated at St. Jude Children ’s Research Hospital. Using a combination of histopathology, whole-genome and whole-exome sequencing, RNA-sequencing, and DNA methylation arrays, we demonstrate the overall fidelity and inter-...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
ConclusionsWe propose that pathogenicPTEN variants may predispose to medulloblastoma, and show that remission was reached with current treatment protocols. ThePTEN gene should be included in the genetic testing provided to patients who develop medulloblastoma at an early age. We recommend brain magnetic resonance imaging upon an unexpected acceleration of growth of head circumference for pediatric patients harboring pathogenic germlinePTEN variants.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
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