S100A4/non-muscle myosin IIA/p53 axis contributes to aggressive features in ovarian high-grade serous carcinoma

S100A4 is a small calcium-binding protein that exerts its biological functions by interacting with non-muscle myosin IIA (NMIIA) and p53. Although S100A4 promotes metastasis in several tumors, little is known about its involvement in the progression of ovarian high-grade serous carcinomas (HGSC). Herein, we focused on functional roles of the S100A4/NMIIA/p53 axis in these tumors. In HGSC cell lines harboring mutant p53 (p53mt), knockdown (KD) of S100A4 reduced the expression of several epithelial-mesenchymal transition (EMT) /cancer stem cell (CSC) markers and the ALDH1high population, consistent with an inhibition of ‘stemness’ features.

Source: American Journal of Pathology - August 13, 2020 Category: Pathology Authors: Ai Hiruta, Yasuko Oguri, Ako Yokoi, Toshihide Matsumoto, Yusuke Oda, Mikihisa Tomohiro, Miki Hashimura, Zesong Jiang, Masataka Tochimoto, Mayu Nakagawa, Makoto Saegusa Tags: Regular Article Source Type: research