Cancers, Vol. 12, Pages 2276: Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Cancers, Vol. 12, Pages 2276: Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach Cancers doi: 10.3390/cancers12082276 Authors: Zeinab Nouri Sajad Fakhri Keyvan Nouri Carly E. Wallace Mohammad Hosein Farzaei Anupam Bishayee Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used in cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence, the discovery and development of novel multi-targeted agents to attenuate the dysregulated signaling in cancer is of great importance. In recent decades, phytochemicals from dietary and medicinal plants have been successfully introduced as alternative anticancer agents due to their ability to modulate numerous oncogenic and oncosuppressive signaling pathways. Rutin (also known as rutoside, quercetin-3-O-rutinoside and sophorin) is an active plant-derived flavonoid that is widely distributed in various vegetables, fruits, and medicinal plants, including asparagus, buckwheat, apricots, apples, cherries, grapes, grapefruit, plums, oranges, and tea. Rutin has been shown to target various inflammatory, apoptotic, autophagic, and angiogenic signaling mediators, including nuclear factor-κB, tumor necrosis factor-α, interleukins, light chain 3/Beclin, B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein, caspases, and vascular endothelial growth factor. A comprehensive and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research