Amino Acids in Health and Endocrine Function.

Amino Acids in Health and Endocrine Function. Adv Exp Med Biol. 2020;1265:97-109 Authors: Flynn NE, Shaw MH, Becker JT Abstract Dietary amino acids play an important role in maintaining health. Branched chain amino acids can adversely increase blood pressure whereas arginine and citrulline can reduce it. D-amino acids play important roles in several cell types including testis, the nervous system and adrenal glands. Several amino acids also can have dramatic effects on diabetes; branched chain amino acids, phenylalanine and tyrosine have been implicated while others, namely arginine and citrulline can improve outcomes. Leucine has been shown to play important roles in muscle primarily through the mTOR pathway though this effect does not translate across every population. Glutamine, arginine and D-aspartate also exert their muscle effects through mTOR. Relationships between amino acids and endocrine function include that of glucocorticoids, thyroid function, glucagon-like peptide 1 (GLP-1), ghrelin, insulin-like growth factor-1 (IGF-1) and leptin. Leucine, for example, can alleviate the effect of dexamethasone on muscle protein accretion. Interestingly, amino acid transporters play an important role in thyroid function. Several amino acids have been shown to increase GLP-1 levels in non-diabetics when administered orally. Similarly, several amino acids increase ghrelin levels in different species while cysteine can decrease it in mice. There is evidence to...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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The objective was to identify the macro- and microangiopathy variables predictive of amputation of the lower extremities (LE) in DT2 patients among.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
Patients presenting type 2 diabetes appear paradoxically protected from the appearance and the evolution of an abdominal aortic aneurysm (AAA). Immune cells take an active part in the weakening of the aortic wall of AAAs, with an important role of the macrophages. Their pro or anti-inflammatory phenotype is partly determined by the cellular metabolism. We hypothesized that diabetes could influence the metabolic phenotype of the macrophages, and thus explain the protective role of diabetes in AAAs.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Therefore, we sought to determine the most important predictors of NAFLD among middle ‑aged men and women in Isfahan, Iran.Methods: A total of 413 individuals (163 men and 250 women) aged 30 –60 years were selected by stratified random sampling. The participants had safe alcohol consumption habits (
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
This study was a cross ‑sectional study. The number of 376 diabetic patients referred to the Diabetes ResearchCenter in Yazd entered the study. The data collection tool was a summary of Diabetes Self CareActivity questionnaire (SDSCA), which was collected through interviews with patients. Dataanalysis was performed using SPSS software V 16 and kruskalwallis and independent sample t tests.Results: The results showed that of 376 patients, 218 (%58) were women and 158 (%42) were male.The mean age of the participants in the study was 54.5 ± 10.9 years old and the mean durationof the disease was 9.53 ± 8.39 year...
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Atal MK, Palei SK, Chaudhary DK, Kumar V, Karmakar NC Abstract Whole-body vibration (WBV) is one of the leading risk factors for the development of musculoskeletal disorder (MSD) that develops symptoms of lower back pain, pain in neck and shoulders, digestive problems, blood pressure and diabetes among professional dumper operators. The present study is specifically aimed at assessing the WBV exposure of 79 dumper operators engaged in two Indian opencast coal mines through vibration measurements followed by questionnaire survey. From daily frequency-weighted rms exposure A(8), it is found that dumper opera...
Source: International Journal of Occupational Safety and Ergonomics - Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research
CONCLUSIONS: The factors associated with hypertension awareness, treatment, and control were different by sex and age group. Enhancing attention on hypertension among young hypertension and encouraging them to visit clinics would be key strategies to improve hypertension management among the young hypertensive population. PMID: 32975054 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSION: Right ventricular pressure overload in APE has an effect on f(QRS-T). In thrombolytic treatment, the change of f(QRS-T) angle may be a marker of successful thrombolysis. PMID: 32975629 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
ahamse Globally, cancer has been identified as one of the leading causes of death in public health. Its etiology is based on consistent exposure to carcinogenic. Plant-derived anticancer compounds are known to be less toxic to the normal cells and are classified into acetylenic compounds, phenolics, terpenes, and phytosterols. Dicoma anomala is a perennial herb belonging to the family Asteraceae and is widely distributed in Sub-Saharan Africa and used in the treatment of cancer, malaria, fever, diabetes, ulcers, cold, and cough. This review aimed at highlighting the benefits of D. anomala in various therapeutic applica...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
The objectives of the study were to describe methods used to measure the progression of IPJ osteoarthritis and identify risk factors for IPJ osteoarthritis progression. MEDLINE, EMBASE, Scopus, and The Cochrane Library were searched from inception to 19th February 2020 (PROSPERO CRD42019121034). Eligible studies assessed potential risk factor/s associated with IPJ osteoarthritis progression. Risk of bias was assessed using a modified QUIPS Tool, and a best evidence synthesis was performed. Of eight eligible studies, all measured osteoarthritis progression radiographically, and none considered symptoms. Eighteen potential r...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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