Black mulberry fruit extract alleviates streptozotocin ‐induced diabetic nephropathy in rats: targeting TNF‐α inflammatory pathway

ConclusionThe ameliorative effect of BMFE on diabetic nephropathy is not only through its potent antioxidant and hypoglycaemic effects but also through its downregulation of TNF ‐α, VCAM‐1 and fibronectin mRNA expression in renal tissues of diabetic‐treated rats. Therefore, BMFE as dietary supplement could be a promising agent in improving diabetic nephropathy.

Source: Journal of Pharmacy and Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Tarek Kamal Abouzed, Kadry M. Sadek, Emad Waded Ghazy, Walied Abdo, Mohmed Atef Kassab, Salma Hago, Samia Abdel ‐Wahab, Engy A. Mahrous, Essam Abdel‐Sattar, Doaa H. Assar Tags: Research Paper Source Type: research