Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events.

CONCLUSION: In ED patients with acute drug overdose and potential indications for SBT, administration of SBT as part of routine clinical care was an independent, dose-dependent, predictor of ACVE, DQTP, and death. This study was not designed to determine whether the SBT or acute overdose itself was causative of ACVE; however, these data suggest that poisoned patients receiving antidotal SBT require close cardiovascular monitoring.
PMID: 32737857 [PubMed - as supplied by publisher]

Source: Journal of Medical Toxicology - July 30, 2020 Category: Toxicology Authors: Shastry S, Ellis J, Loo G, Vedanthan R, Richardson LD, Manini AF Tags: J Med Toxicol Source Type: research