Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves.

CONCLUSIONS: Our in vitro results showed a trend to decline in NGF and BDNF mRNA in ML-treated hSC, compared to controls. The immunodetection of BDNF and NT-4 was significantly downregulated in ML-treated hSC. Conversely, ML-infected mice demonstrated upregulation of NT-3, compared to non-infected animals. Our findings indicate that ML may be involved in neurotrophins regulation, suggesting that a pathogen-related imbalance of these growth factors may have a role in the neural impairment of leprosy.
PMID: 32696914 [PubMed - in process]

Source: Memorias do Instituto Oswaldo Cruz - July 25, 2020 Category: Infectious Diseases Authors: Nogueira MRS, Amôr NG, Michellin LB, Cury Filho M, Rosa PS, Latini ACP, Rodrigues LS, Lemes RMR, Lara FA, Pessolani MCV Tags: Mem Inst Oswaldo Cruz Source Type: research