The association of rs2233679 in the PIN1 gene promoter with the risk of Coronary Artery Disease in Chinese female individuals

Cerebral vascular dysfunction is associated with various neurological disorders, which often share some common mechanisms with cardiovascular diseases especially Coronary Artery Disease (CAD).1 –6 Pin1 (encoded by the PIN1 gene) is a key enzyme in humans and is implicated in Alzheimer disease by suppressing amyloid–β deposition and tau aggregation.7–11 Recently, we hypothesized that Pin1 may cause cerebrovascular atherosclerosis and aggravate ischemia-related neurological disorders. 12 However, the relationship between the genetic polymorphisms of PIN1 and vascular atherosclerosis in humans is still not clear.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research