Natural α , β -unsaturated lactones inhibit neuropeptide-induced mast cell activation in an in vitro model of neurogenic inflammation

ConclusionsThese results are the first strong evidence supporting the hypothesis that dehydroleucodine and xanthatin inhibit substance P- and neurotensin-induced serotonin release from rat peritoneal mast cells. Our findings suggest, additionally, that theseα,β-unsaturated lactones could be of value in future pharmacological research related to inappropriate mast cell activation conditions such as neurogenic inflammation and neuropathic pain.

Source: Inflammation Research - July 13, 2020 Category: Research Source Type: research