Chitosan-Based Delivery of Avian Reovirus Fusogenic Protein p10 Gene: In Vitro and In Vivo Studies towards a New Vaccine against Melanoma.

In conclusion, we proved that in vitro ARV-p10 protein expression using CH-NPs in murine melanoma cells induces a cytotoxic effect associated with its cell fusion. Further studies are necessary for establishing a protocol for efficient in vivo DNA delivery of fusion proteins to produce an antitumoral effect.
PMID: 32626742 [PubMed - in process]

Source: Biomed Res - July 8, 2020 Category: Research Authors: Robles-Planells C, Barrera-Avalos C, Rojo LE, Spencer E, Cortez-San Martin M, Matiacevich S, Pavez J, Milla LA, Navarro FD, Martínez BA, Bravo FJ, Mella A, Huidobro-Toro JP, Fernandez R, Escobar A, Castillo CA Tags: Biomed Res Int Source Type: research