Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice
Horm Metab Res DOI: 10.1055/a-1199-2257The C57BL/6J (B6J) mouse strain has been widely used as a control
strain for the study of metabolic diseases and diet induced obesity (DIO).
B6J mice carry a spontaneous deletion mutation in the nicotinamide
nucleotide transhydrogenase (Nnt) gene eliminating exons
7–11, resulting in expression of a truncated form of Nnt, an
enzyme that pumps protons across the inner mitochondrial membrane. It has
been proposed that this mutation in B6J mice is associated with epigonadal
fat mass and altered sensitivity to diet induced obesity. To define the role
of Nnt in the development of diet induced obesity, we generated first
backcross (BC1) hybrids of wild type Nnt C57BL/6NTac and
mutated Nnt C57BL/6JRj
[(C57BL/6NTac×C57BL/6JRj)F1×C57BL/6NTac].
Body weight gain and specific fat-pad depot mass were measured in BC1
hybrids under high fat diet conditions. Both sexes of BC1 hybrids indicate
that mice with Nnt wild type allele are highly sensitive to DIO and
exhibit higher relative fat mass. In summary, our data indicate that the
Nnt mutation in mice is associated with sensitivity to DIO and
fat mass. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Kunath, Anne Heiker, John T. Kern, Matthias Kosacka, Joanna Flehmig, Gesine Stumvoll, Michael Kovacs, Peter Bl üher, Matthias Kl öting, Nora Tags: Endocrine Research Source Type: research
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