Combined treatment with ultrasound-targeted microbubble destruction technique and NM-aFGF-loaded PEG-nanoliposomes protects against diabetic cardiomyopathy-induced oxidative stress by activating the AKT/GSK-3 β1/Nrf-2 pathway.

This study confirmed using PEGylated nanoliposomes combined with the UTMD technique can effectively deliver NM-aFGF to the cardiac tissue of diabetic rats. The NM-aFGF can then inhibit myocardial oxidative stress damage due to DM by activating the AKT/GSK/Nrf-2 signaling pathway, which ultimately improved the myocardial structural and functional lesions in diabetic rats. PMID: 32611270 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32611270?dopt=Abstract

Source: Drug Delivery - July 4, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research