Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease.

This article summarizes the available evidence implicating the following RAMPs in CNS physiological processes and neurodegenerative diseases: cardiolipin (CL), prothymosin α (ProTα), binding immunoglobulin protein (BiP), heat shock protein (HSP) 10, HSP 27, and αB-crystallin. Studies on the molecular mechanisms engaged by RAMPs could identify novel glial targets for development of therapeutic agents that effectively slow down neuroinflammatory disorders including AD. PMID: 32614758 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32614758?dopt=Abstract

Source: CNS and Neurological Disorders Drug Targets - July 1, 2020 Category: Drugs & Pharmacology Authors: Wenzel TJ, Kwong E, Bajwa E, Klegeris A Tags: CNS Neurol Disord Drug Targets Source Type: research